Distinguished Professor
UC Davis
Sacramento, California
Paul Hagerman, MD, PhD, is a molecular geneticist who has focused his research effort on disorders related to the fragile X (FMR1) gene for over twenty years, before which his main area of research was nucleic acid biochemistry. In 2000, his lab discovered the molecular basis for FXTAS as toxicity of the CGG-repeat-containing RNA, which is dramatically overexpressed in premutation carriers. He and his wife, Randi Hagerman, MD, have established a brain repository for both premutation and full mutation CNS tissues. Finally, the Hagerman lab has isolated and characterized the proteome of the intranuclear neural cell inclusions, a pathologic hallmark of FXTAS, identifying over 5,000 proteins within the inclusions, with proteins SUMO2 and p62/SQSTM, involved with aggregate removal, as the most prominent species.
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